Antifungal efficacy of oxythiamine – antivitamin derivative of vitamin B1

Grażyna Ziółkowska

Akademia Rolnicza w Lublinie

Stanisław Tokarzewski

Akademia Rolnicza w Lublinie

Sławomir Strumiło

Uniwersytet w Białymstoku

Adam Tylicki

Uniwersytet w Białymstoku

Abstract

The in vitro antifungal activity (MIC, MFC) of oxythiamine was assessed against 15 dermatophyte strains, 9 moulds and 24 yeast-like fungi. High activity of oxythiamine was determined towards Malassezia pachydermatis strains (n = 10); in this case MIC was found within 1.25–2.5 g ml^-1. The biocidal efficacy (MFC) of oxythiamine was not recorded in any drug dose applied.

Keywords:

oxythiamine, antifungal efficacy, MIC, MFC