Abstrakt
Kisspeptyna (KiSS) i jej konstytutywny receptor GPR-54 odgrywają kluczową rolę w regulacji osi podwzgórze–przysadka–gonady (HPG), wpływając m.in. na aktywację gonadotropin osi w okresie dojrzewania człowieka. Potwierdzono, że mutacje w genie KiSS-1 i GPR-54 mogą odgrywać istotną rolę w patogenezie CPP (wczesnego dojrzewania) i IHH (idiopatycznego hipogonadyzmu hipogonadotropowego). Rola zmienności w sekwencji genów KiSS1/GPR54 u innych ssaków jest poznana w niewielkim zakresie, a doniesienia o związku polimorfizmów z parametrami użytkowości rozpłodowej zwierząt gospodarskich są rozbieżne i wymagają kontynuowania badań.
Bibliografia
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