The experiment was carried out at the Experimental Station of Tobacco Cultivation in Zamosc between 1996 and 1998. The tested factor was the reaction of flue-cured tobacco cultivar ‘Wislica’ to differentiated nitrogen fertilizing. Two kinds of fertilizers were used: ammonium nitrate and calcium nitrate in rates between 0 up to 45 kg N ha-1. Increase of nitrogen fertilizing improved the yield of leaves but at the same time made the raw material quality worse. Calcium nitrate fertilizing caused a decrease of light grades share and carbohydrates content as well but on the other hand it increased nicotine and protein content. The economic analysis proved that despite the decrease of leaves quality much more profitable effects were obtained after ammonium nitrate application.