Teresa Grzelak

Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland

Joanna Grupińska

Poznań University of Medical Science, Poland

Marta Pelczyńska

Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland

Marcelina Sperling

Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland

Krystyna Czyżewska

Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland


Carbohydrate and protein replacers of fat are frequently used by food manufacturers in response to the increased risk of diseases, which are connected with oversupply of energy and lipids in the diet. Low-calorie replacers such as inulin can limit hunger and normalize blood cholesterol levels. Increases in the nutritional value of food products can be achieved by partially replacing fat by soy protein isolates. Amino acids and deficient minerals like calcium and iron can be provided by food containing protein-based fat substitutes. Some fat substitutes, like maltodextrin, can slightly reduce the bioavailability of the fat-soluble vitamins. As a result, food products containing maltodextrin should be fortified with the affected substances to reduce the risk of malnutrition. The long-term effects of carbohydrate and protein replacers on the human body have not been sufficiently explained, and so fat replacers should be limited in the daily diet.


fat substitutes, inulin, maltodextrin, protein isolates

Arcia, P.L., Costell, E., Tarrego, A. (2011). Inulin blend as probiotic and fat replacer in dairy desserts: Optimization by response surface methodology. J. Dairy Sci., 94(5), 2192–2200.
Barclay, T., Ginic-Markovic, M., Cooper, P., Petrovsky, N. (2010). Inulin – a versatile polysaccharide with multiple pharmaceutical and food chemical uses. J. Excip. Food Chem., 1(3), 27–50.
Baylin, A. (2013). Secular trends in trans fatty acids decreased trans fatty acids in the food supply are reflected in decreased trans fatty acids in plasma. Am. J. Clin. Nutr., 97(4), 665–666.
Bogumil, A., Dawidek, B., Lewandowska, M., Pawelec-Potapska, M., Wojciechowski, M., Wroblewska, A. (2013). Food economy. In: Statistical yearbook of agriculture, Łaczynski, A., Ziołkowska, E. (eds). Warsaw, Statistical Publishing Establishment, pp. 342–358.
Bonsu, N.K.A., Johnson, C.S., Mcleod, K.M. (2011). Can dietary fructans lower serum glucose? J. Diabetes, 3(1), 58–66.
Chamba, M.V.M., Hua, Y., Simwaka, J.E. (2014). Comparative sensory evaluation of soy protein isolates extracted from full-fat and defatted flours using natural and conventional synthetic extraction chemicals. Food Res. Int., 21(1), 209–215.
Charalampopoulos, D., Rastall, R.A. (2012). Prebiotics in food. Curr. Opin. Biotechnol., 23(2), 187–191.
Chugh, B., Singh, G., Kumbhar, B.K. (2013). Development of low-fat soft dough biscuits using carbohydrate-based fat replacers. Int. J. Food Sci. doi:10.1155/2013/576153
Coxam, V. (2007). Current data with inulin-type fructans and calcium, targeting bone health in adults. J. Nutr., 137(11), 2527S–2533S.
Dehghan, P., Gargari, B.P., Jafar-Abadi, M.A. (2014). Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial. Nutrition, 30(4), 418–423.
Ebneter, D.S., Latner, J.D., Nigg, C.R. (2013). Is less always more? The effects of low-fat labelling and caloric information on food intake, calorie estimates, taste preference, and health attributions. Appetite, 68, 92–97.
EFSA (2010). European Food Safety Authority. Scientific Committee/Scientific Panel. Scientific opinion on dietary reference values for fat, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids and cholesterol. EFSA J. doi:10.2903/j.efsa.2010.1461
FAO (2008). Food and Agriculture Organization of the United Nations. Interim summary of conclusions and dietary recommendations on total fat and fatty acids. Fats and fatty acids in human nutrition. Report for an expert consultation, Geneva.
Forcheron, F., Beylot, M. (2007). Long-term administration of inulin-type fructans has no significant lipidlowering effect in normolipidemic humans. J. Clin. Endocr. Metab., 56(8), 1093–1098.
Gargari, B.P., Dehghan, P., Aliasgharzadeh, A., Jafar-Abadi, M.A. (2013). Effects of high performance inulin supplementation on glycemic control and antioxidant status in women with type 2 diabetes. Diab. Metab. J., 37(2), 140–148.
Garnero, C., Aloisio, C., Longhi, M. (2013). Ibuprofenmaltodextrin interaction: study of enantiomeric recognition and complex characterization. Pharmacol. Pharm., 4(1), 18–30.
Guardeno, L.M., Vazquez-Gutierrez, J.L., Hernando, I., Quiles, A., 2013. Effect of different rice starches, inulin, and soy protein on microstructural, physical, and sensory properties of low-fat, gluten, and lactose free white sauces. Czech J. Food Sci., 31(6), 575–580.
Hadnađev, M., Hadnađev, T.D., Dokić, L., Pajin, B., Torbica, A., Šarić, L., Ikonić, P. (2014). Physical and sensory aspects of maltodextrin gel addition used as fat replacers in confectionery filling systems. Food Sci. Technol. doi:10.1016/j.lwt.2014.04.044
Hijova, E., Szabadosova, V., Stofilova, J., Hrckova, G. (2013). Chemopreventive and metabolic effects of inulin on colon cancer development. J. Vet. Sci., 14(4), 387–393.
Ischimura, A., Hirasawa, A., Hara, T., Tsujimoto, G. (2009). Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostagl. Other Lipid Mediat., 89, 82–88.
Jarlenski, M., Barry, C.L. (2013). News media coverage of trans fat: health risks and policy responses. Health Commun., 28(3), 209–216.
Jing, H., Yap, M., Wong, P.Y.Y., Kitts, D.D. (2011). Comparison of physicochemical and antioxidant properties of egg-white proteins and fructose and inulin Maillard reaction products. Food Bioproc. Technol., 4, 1489–1496.
Kalman, D., Feldman, S., Martinez, M., Krieger, D.R., Tallon, M.J. (2007). Effect of protein source and resistance training on body composition and sex hormones. J. Int. Soc. Sports Nutr., 4(4), 1–8.
Kalogeropoulos, N., Panagiotakos, D.B., Pitsavos, C., Chrysohoou, C., Rousinou, G., et al. (2010). Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults. Clin. Chim. Acta, 411, 584–591.
Koecher, K.J., Noack, J.A., Timm, D.A., Klosterbuer, A.S., Thomas, W., Slavin, J.L. (2014). Estimation and interpretation of fermentation in the gut: coupling results from a 24h batch in vitro system with fecal measurements from a human intervention feeding study using fructooligosaccharides, inulin, gum acacia and pea fiber. J. Agric. Food Chem., 62, 1332–1337.
Kolida, S., Tuohy, K., Gibson, G.R. (2002). Prebiotic effects of inulin and oligofructose. Br. J. Nutr., 87, Suppl. 2, S193–S197.
Kuntz, M. G.F., Fiates, G.M.R., Teixeira, E. (2013). Characteristics of prebiotic food products containing inulin. Brit. Food J., 115(2), 235–251.
Liu, L., Allemekinders, H., Dansby, A., Campbell, L., Durance-Tod, S., et al. (2013). Evidence of health benefits of canola oil. Nutr. Rev., 71(6), 370–385.
Macfarlane, G.T., Macfarlane, S. (2011). Fermentation in the human large intestine. Its physiologic consequences and the potential contribution of prebiotics. J. Clin. Gastroenterol., 45, S120–S127.
Martin, C.K., Rosenbaum, D., Han, H., Geiselman, P.J., Wyatt, H.R., et al. (2011). Change in food cravings, food preferences, and appetite during a low-carbohydrate and low-fat diet. Obesity, 19(10), 1963–1970.
McDaniel, J., Ickes, E., Holloman, Ch. (2013). Beneficial n-3 polyunsaturated fatty acid levels and n6:n3 ratios after 4-week EPA + DHA supplementation associated with reduced CRP: A pilot study in healthy young adults. MRI, 2(4), 59–68.
Meyer, D., Bayarri, S., Tarrega, A., Costell, E. (2011). Inulin as texture modifier in dairy products. Food Hydrocolloid., 25(8), 1881–1890.
Miyazato, S., Nakagawa, C., Kishimoto, Y., Tagami, H., Hara, H. (2010). Promotive effects of resistant maltodextrin on apparent absorption of calcium, magnesium, iron, zinc in rats. Eur. J. Nutr., 49, 165–171.
Morris, C., Morris, G.A. (2012). The role of inulin and fructo-oligosaccharide supplementation on the textural, rheological and sensory properties of bread and their role in weight management: A review. Food Chem., 133(2), 237–248.
Ng, J., Stice, E., Yokum, S., Bohon, C. (2011). An fMRI study of obesity, food reward, and perceived caloric density. Does a low-fat label make food less appealing? Appetite, 57, 65–72.
Niki, E., Traber, M.G. (2012). A history of vitamin E. Ann. Nutr. Metab., 61, 207–212
Pavese, J.M., Farmer, R.L., Bergancorresponding, R.C. (2010). Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metast. Rev., 29(3), 465–482.
Psimouli, V., Oreopoulou, V. (2013). The effect of fat replacers on batter and cake properties. J. Food Sci., 78(10), 1495–1502.
Sahan, N., Yasar, K., Hayaloglu, A.A., Karaca, O.B., Kaya, A. (2008). Influence of fat replacers on chemical composition, proteolysis, texture profiles, meltability and sensory properties of low-fat Kashar cheese. J. Dairy Res., 75(1), 1–7.
Salvatore, E., Pes, M., Mazzarello, V., Pirisi, A. (2014). Replacement of fat with long-chain inulin in a fresh cheese made from caprine milk. Int. Dairy J., 34, 1–5.
Siva Kumar, S., Balasubramanian, S., Biswas, A.K., Chatli, M.K., Devatkal, S.K., et al. (2011). Efficacy of soy protein isolate as a fat replacer on physico-chemical and sensory characteristics of low-fat paneer. J. Food Sci. Technol., 48(4), 498–501.
Sobolewska-Zielinska, J., Fortuna, T. (2010). Retrogradation of starches and maltodextrins of origin various. Acta Sci. Pol. Technologia Alimentaria, 9(1), 71–81.
Soto, M.J.L., Garcia, M.L., Gonzalez, V.J., Nicanor, B.A., Cruz, G.L. (2012). Influence of starch source in the required hydrolysis time for the production of maltodextrins with different dextrose equivalent. Afr. J. Biotechnol., 69(11), 13428–13435.
Squadrito, F., Marini, H., Bitto, A., Altavilla, D., Polito, F., et al. (2013). Genistein in the metabolic syndrome: results of a randomized clinical trial. J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2013-1180
Takeiti, C.Y., Kieckbusch, T.G., Collares-Queiroz, F.P.
(2010). Morphological and physicochemical characterization
of commercial maltodextrins with different degrees
of dextrose – equivalent. Int. J. Food Prop., 13(2),
Udomrati, S., Ikeda, S., Gohtami, S. (2013). Rheological
properties and stability of oil-in-water emulsions containing
tapioca maltodextrin in the aqueous phase.
J. Food Eng., 116(1), 170–175.
Untea, A., Criste, R.D., Taranu, I., Souffrant, W.B.,
Janczyk, P., et al. (2013). Availability of microelements
in recently weaned piglets fed diet supplemented
with inulin. Czech J. Anim. Sci., 58(8), 369–374.
Wakai, K., Naito, M., Date, Ch., Iso, H., Tamakoshi, A., et
al. (2014). Dietary intakes of fat and total mortality
among Japanese populations with a low fat intake: the
Japan Collaborative Cohort (JACC) Study. Nutr.
Metabol. doi:10.1186/1743-7075-11-12
Wu, T., Yang, Y., Zhang, L., Han, J. (2010). Systematic
review of the effects of inulin-type fructans on blood
lipid profiles: a meta-analysis. Wei. Sheng. Yan. Jiu.,
39(2), 172–176.
Yu, Z., Yin, Y., Zhao, W., Chen, F., Liu, J. (2014). Application
and bioactive properties of proteins and peptides
derived from hen eggs: opportunities & challenges.
J. Agric. Food Chem. doi:10.1002/jsfa.6670
Yu, Z.P., Zhao, W.Z., Liu, J.B., Lu, J., Chen, F. (2011).
QIGLF, a novel angiotensin I-converting enzymeinhibitory
peptide from egg white protein. J. Sci. Food
Agric., 91, 921–926.
Zahn, S., Pepke, F., Rohm, H. (2010). Effect of inulin as
a fat replacer on texture and sensory properties of muffins.
Int. J. Food Sci. Technol., 45(12), 2531–2537.
Zhang, Y., Tan, C., Zhang, X., Xia, S., Jia, C., Eric, K.,
Abbas, S., Feng, B., Zhong, F. (2014). Effects of
maltodextrin glycosylation following limited enzymetic
hydrolysis on the functional and conformational
properties of soybean protein isolate. Eur. Food Res.
014-2164-5 (accessed 15 May 2014).


Teresa Grzelak 
Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland
Joanna Grupińska 
Poznań University of Medical Science, Poland
Marta Pelczyńska 
Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland
Marcelina Sperling 
Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland
Krystyna Czyżewska 
Department of the Biology of Civilization-Linked Diseases, Poznań University of Medical Science, Święcickiego 6, 60-781 Poznań, Poland



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