Abstrakt
Białko HSPB1, z rodziny małych białek szoku cieplnego (sHsps), pełni funkcjonalną rolę w regulacji wielu procesów wewnątrzkomórkowych oraz ochronie przed stresowymi czynnikami środowiskowymi. Mutacje genu HSPB1 są przyczyną dysfunkcji komórek neuronowych, związanych z miopatiami, neuropatiami motorycznymi i zaburzeniami neurodegeneracyjnymi, w tym równieŜ z chorobami prionowymi. Precyzyjna, chromosomowa lokalizacja tego genu moŜe przyczynić się do identyfikacji nowego QTL skorelowanego z opornością/podatnością na choroby prionowe u bydłowatych. W wyniku porównawczego mapowania przeprowadzonego techniką FISH z gatunkowo specyficznymi i heterologicznymi sondami molekularnymi określono lokalizację genu HSPB1 w regionie 25q22 genomu bydła i kóz oraz 24q22 owiec. Fizyczna lokalizacja tego genu w genomach badanych gatunków określiła jego przynaleŜność do grup sprzęŜeniowych i syntenicznych, co jest istotne dla przewidywania skutków selekcji genetycznej.
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