In the GC-MS analysis, 81 bioactive phytochemical compounds were identified in the hexane extracts of Cirsium creticum and Cirsium italicum. Terpenoids constituted the main fractions of C. italicum (70.95 %) while hydrocarbons were most abundant compounds of C. creticum (41.11 %). The antibacterial activity and antifungal activity of extracts from two Cirsium species was tested by using microdilution methods. According to the results of antibacterial activity, highest inhibition effect of C. creticum was found on B. subtilis, E. coli and P. aeruginosa. The highest inhibition effect of C. italicum was found on B. subtilis. In the results of antifungal activity, highest inhibition effect of C. creticum was found on P. chrysogenum and highest inhibition effect of C. italicum was found on C. krusei. The present work is the first report on hexane extracts compounds of two Cirsium species as well as the antibacterial and antifungal activities.


antibacterial activity; antifungal activity; C. creticum; C. italicum; active compounds

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Published : 2019-10-30

Gulen, D., Sabudak, T., Orak, H., Caliskan, H., & Ozer, M. (2019). BIOACTIVE COMPOUNDS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF TWO Cirsium SPECIES. Acta Scientiarum Polonorum Hortorum Cultus, 18(5), 213-221.

Dumrul Gulen 
Department of Medical Microbiology School of Medicine, Namik Kemal University, Tekirdag, Turkey  Turkey
Temine Sabudak
Department of Chemistry, Faculty of Science and Arts, Namik Kemal University, Tekirdag, Turkey  Turkey
Hakime H. Orak 
Department of Food Technology, Vocational School of Technical Sciences, Namik Kemal University, Tekirdag, Turkey  Turkey
Hilmican Caliskan 
Department of Chemistry, Faculty of Science and Arts, Namik Kemal University, Tekirdag, Turkey  Turkey
Merve Ozer 
Department of Chemistry, Faculty of Science and Arts, Namik Kemal University, Tekirdag, Turkey  Turkey


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