BIOACTIVE COMPOUNDS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF TWO Cirsium SPECIES
In the GC-MS analysis, 81 bioactive phytochemical compounds were identified in the hexane extracts of Cirsium creticum and Cirsium italicum. Terpenoids constituted the main fractions of C. italicum (70.95 %) while hydrocarbons were most abundant compounds of C. creticum (41.11 %). The antibacterial activity and antifungal activity of extracts from two Cirsium species was tested by using microdilution methods. According to the results of antibacterial activity, highest inhibition effect of C. creticum was found on B. subtilis, E. coli and P. aeruginosa. The highest inhibition effect of C. italicum was found on B. subtilis. In the results of antifungal activity, highest inhibition effect of C. creticum was found on P. chrysogenum and highest inhibition effect of C. italicum was found on C. krusei. The present work is the first report on hexane extracts compounds of two Cirsium species as well as the antibacterial and antifungal activities.
antibacterial activity; antifungal activity; C. creticum; C. italicum; active compounds
Berger, A., Jones, P.J.H. (2004). Abumweis SS. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis., 3(5), 1–19.
Borawska, M.H., Czechowska, S.K., Markiewicz, R., Socha, K., Nazaruk, J., Palka, J., Isidorov, V.A. (2010). Enhancement of antibacterial effects of extracts from Cirsium species using sodium picolinate and estimation of their toxicity. Nat. Prod. Res., 24(6), 554–561.
CLSI (2008). Reference method for broth dilution antifungal susceptibility testing of yeasts, Approved Standard 3rd ed., CLSI M27-A3. Clinical and Laboratory Standards Institute, Wayne.
CLSI (2017). Performance standards for antimicrobial susceptibility testing, 27th ed., CLSI M100. Clinical and Laboratory Standards Institute, Wayne.
El-Sakhawy, F.S., El-Tantawy, M.E., Ross, S.A., El-Sohly, M.A. (1998). Composition and antimicrobial activity of the essential oil of Murraya exotica L. Flav. Frag. J., 13, 59–62.
Gallo, M.B.C., Sarachine, M.J. (2009). Biological activities of Lupeol. Int. J. Biomed. Pharm. Sci., 3(Special issue), 46–66.
Genc, G.E., Ozhatay, N. (2006). An ethnobotanical study in Çatalca (European part of Istanbul) II. Turk. J. Pharm. Sci., 3, 73–89.
Gomez, M.A., Saenz, M.T., Garcia, M.D., Fernandez, M.A. (1999). Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models. Z. Naturforsch. C, 54(11),
Hamberger, A., Stenhagen, G. (2003). Erucamide as a modulator of water balance: new function of a fatty acid amide. Neurochem. Res., 28, 177–185.
Kim, J.G. (1997). Illustrated natural drugs encyclopedia (Color edition). Nam San Dang, Seuol, 1, 37.
Kim, E.Y., Jho, H.K., Kim, D.I., Rhyu, M.R. (2008). Cirsium japonicum elicits endothelium-dependent relaxation via histamine H1-receptor in rat thoracic aorta. J. Ethnopharm., 116, 223–227.
Kizilarslan, C., Ozhatay, N. (2012). An ethnobotanical study of the useful and edible plants of İzmit. Marmara Pharm. J., 16, 194–200.
Lay-Jing, S., Hooi-Kheng, B., Pazillah, I., Amirin, S., Mohd, Z.A. (2012). Antimicrobial activity of Gynura segetum’s leaf extracts and its active fractions. Int. J. General Trad. Med., 2, 1–5.
Nazaruk, J., Czechowska, S.K., Markiewicz, R., Borawska, M.H. (2008). Polyphenolic compounds and in vitro antimicrobial and antioxidant activity of aqueous extracts from leaves of some Cirsium species. Nat. Prod. Res., 22(18), 1583–1588.
Perez, G.R.M., Ramirez, L.M., Vargas, S. (2001). Effect of Cirsium pascuarense on blood glucose levels of normoglycaemic and alloxan-diabetic mice. Phytother. Res., 15, 552–554.
Reddy, P.S., Jamil, K., Madhusudhan, P. (2001). Antibacterial activity of isolates from Piper longum and Taxus baccata. Pharm. Biol., 39, 236–238.
Reifen, R., Karlinsky, A., Stark, A.H., Berkovich, Z., Nyska, A. (2015). α-linolenic acid (ALA) is an anti-inflammatory agent in inflammatory bowel disease. J. Nutr. Biochem., 26, 1632–1640.
Runyoro, D., Matee, M., Olipa, N., Joseph, C., Mbwambo, H. (2006). Screening of Tanzanian medicinal plants for anti-candida activity. BMC Complement. Altern. Med., 6, 11.
Sabudak, T., Goren, A.C. (2011). Volatile composition of Trifolium and Medicago species. J. Essent. Oil Bear. Plants., 14 (4), 401–407.
Smaoui, S., Mathieu, F., Fguira, B.F., Lilia, M., Georges, M.L. (2012). Taxonomy, purification and chemical characterization of four bioactive compounds from new Streptomyces sp. TN256 strain. World J. Microbiol. Biotech., 28, 793–804.
Srivastava, D., Singh, P. (2015). In vitro fungitoxic evaluation an GC MS analysis of Calotropis procera. World J. Pharm. Res., 4, 1123–1135.
Tan, M., Zhou, L.G., Huang, Y., Wang, Y., Hao,X., Wang, J. (2008). Antimicrobial activity of globulol isolated from the fruits of Eucalyptus globulus Labill. Nat. Prod. Res., 22, 569.
Wakamatsu, K., Masaki, T., Itoh, F., Kondo, K., Sudo, K. (1990). Isolation of fatty acid amide as an angiogenic principle from bovine mesentery. Biochem. Biophys. Res. Commun., 168, 423–429.
Yesilada, E., Sezik, E., Honda, G., Takaishi, Y., Takeda, Y., Tanaka, T. (1999). Traditional medicine in Turkey IX: Folk medicine in North-west Anatolia. J. Ethnopharm., 64, 195–210.
Yoo, Y.M., Nam, J.H., Kim, M.Y., Choi, J., Park, H.J. (2008). Pectolinarin and Pectolinarigenn of Cirsium setidens prevent the hepatic injury in rats caused by D-galactosamine via an antioxidant mechanism. Biol. Pharm. Bull., 31, 760–764.
Youngwan, S., Ki Eui, P., You, A.K., Hee-Jung, L., Jong-Su, Y., Jong-Woong, A. (2006). Burm-Jong L. isolation of tetraprenyltoluquinols from the Browm Alga Sargassum thunbergii. Chem. Pharm. Bull., 54(12), 1730–1733.
Articles are made available under the CC BY-NC-ND 4.0 (recognition by authorship, non-commercial use, no dependent works).
The author signs a statement on the originality of the work and the contribution of individuals.
Submission of the paper implies that it has not been published previously, that it is not under consideration for publication elsewhere.