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Tom 76 Nr 3 (2021)

Artykuły

Podłoże genetyczne biosyntezy laktonów seskwiterpenowych u Asteraceae. Praca przeglądowa

DOI: https://doi.org/10.24326/as.2021.3.4
Przesłane: 2 sierpnia 2021
Opublikowane: 19.11.2021

Abstrakt

Rodzina Asteraceae jest bogatym źródłem wielu laktonów seskwiterpenowych. Te metabolity wtórne odznaczają się wielokierunkowym działaniem, w tym aktywnością przeciwnowotworową, przeciwzapalną czy przeciwdrobnoustrojową. Inżynieria metaboliczna jest obiecującym podejściem, które pozwala na zwiększenie produkcji laktonów seskwiterpenowych poprzez rekonstrukcję szlaku ich biosyntezy w systemach heterologicznych. Ponadto, ich produkcja  może zostać zwiększona w gatunkach roślin, w których naturalnie występują, poprzez nadekspresję genów zaangażowanych w szlak ich biosyntezy i/lub czynników transkrypcyjnych pozytywnie regulujących szlak. Każda z tych strategii wymaga szczegółowej wiedzy dotyczącej podłoża genetycznego szlaku biosyntezy laktonów seskwiterpenowych. Niniejsza praca przeglądowa podsumowuje badania molekularne dotyczące biosyntezy tych niezwykle cennych z punktu widzenia farmakologicznego metabolitów wtórnych.

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