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ASPHC Baner

Vol. 19 No. 3 (2020)

Articles

POT MARIGOLD (Calendula officinalis L.) – A POSITION IN CLASSICAL PHYTOTHERAPY AND NEWLY DOCUMENTED ACTIVITIES

DOI: https://doi.org/10.24326/asphc.2020.3.5
Submitted: March 14, 2019
Published: 2020-06-29

Abstract

The flower (inflorescence, basket-type inflorescence) of marigold (Calendulae officinalis flos) is a well-known plant raw material in traditional phytomedicine. Noteworthy is its rich chemical composition, which is dominated by flavonoids and terpenoids. Terpenoids are mainly represented by specific for this species oleanolic acid derivatives: triterpenoid saponins – calendulosides A-H and triterpenoid glycosides, so-called calendulaglycosides A and B. The biological activity profiles of the raw material, such as anti-inflammatory, antimicrobial, immunostimulatory and antioxidant properties, determine its use especially in the treatment of dermatological diseases. Interestingly, recent scientific studies proved, in addition to spasmolitic, hypolipemic and antidiabetic properties, such heath promoting activity as cardioprotective, hepatoregenerative, pancreas regenerating, neuroprotective and even anticancer activities. Moreover, C. officinalis is used in cosmetology and food industry.

References

  1. Aghajanyan, A.A., Trchounian, A.H. (2018). Antihyperglicemic properties of the herbal mixture. Chem. Biol., 52(3), 180–186.
  2. Alexandre, J.T.M., Sousa, L.H.T., Lisboa, M.R.P., Furlaneto, F.A.C., Do Val, D.R., Marques, M., Vasconcelos, H.C., Matos de Melo, I., Leitao, R., Brito G.A.C., Goes, P. (2018). Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats. Clin. Oral Investig., 22(6), 2175–2185. DOI: 0.1007/s00784-017-2308-7
  3. Anuradha, S.N., Vilashene, G., Lalithambigai, J., Arunkumar, S. (2015). “Cosmeceuticals”: An opinion in the direction of pharmaceuticals. Asian J. Pharm. Clin. Res., 8(2), 64–69.
  4. Arora, D., Rani, A., Sharma, A. (2013). A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacog. Rev., 7(14), 179. DOI: 10.4103/0973-7847.120520
  5. Bakó, E., Deli, J., Tóth, G. (2002). HPLC study on the carotenoid composition of Calendula products. J. Bioch. Biophys. Methods, 53, 241–250. DOI: 10.1016/S0165-022X(02)00112-4
  6. Banakar, S.M., Veerapur, V.P., Thippeswamy, B.S., Jagadeesh, N.V., Gavimath, C.C., Alshehri, Z.S. (2016). Protective effect of Calendula officinalis (L.) flower extract in acetic acid-induced ulcerative colitis in rats. J. Herbs, Spices Med. Plants, 22(3), 225–237. DOI: 10.1080/10496475.2016.1190952
  7. Basch, E., Bent, S., Foppa, I., Haskmi, S., Kroll, D., Mele, M., Szapary, P., Ulbricht, C., Voa, M., Vora, M., Yong, S. (2006). Marigold (Calendula officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J. Herb. Pharmacother., 6(3–4), 135–159. DOI: 10.1080/J157v06n03_08
  8. Bingen, H. von (1155). Hildegard von Bingen’s Physica.
  9. Buzzi, M., Freitas, F. de, Barros Winter, M. de (2016). Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing. J. Wound Care, 25(12), 732–739. DOI: 10.12968/jowc.2016.25.12.732
  10. Colombo, E., Sangiovanni, E., D’Ambrosio, M., Bosisio, E., Ciocarlan, A., Fumagalli, M., Guerriero A., Harghel P., Dell’Agli, M. (2015). A bio-guided fractionation to assess the inhibitory activity of Calendula officinalis L. on the NF-B driven transcription in human gastric epithelial cells. Evid.-Based Complement. Altern. Med., 2, 727342. DOI: 10.1155/2015/727342
  11. Corazza, M., Borghi, A., Gallo, R., Schena, D., Pigatto, P., Lauriola, M.M., Guarneri, F., Stngeni, L., Vincenzi, C., Foti, C., Virgili, A. (2014). Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study. Contact Dermatitis, 70(2), 90–97. DOI: 10.1111/cod.12124
  12. Cordova, C., Siqueira, I., Netto, C. (2002). Protective properties of butanolic extract of the Calendula officinalis L. (marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger. Redox Rep., 7(2), 95–102. DOI: 10.1179/135100002125000325
  13. CosIng – Cosmetic Ingredient Database. Available: https://ec.europa.eu/growth/sectors/cosmetics/cosing_en [data of access: 06.12.2018].
  14. Denisow-Pietrzyk, M., Pietrzyk, Ł. (2019). Asteraceae species as potential environmental factors of allergy. Environ. Sci. Pollut. Res. 26(1), 1–11. DOI: 10.1007/s11356-019-04146-w
  15. Dinda, M., Dasgupta, U., Singh, N., Bhattacharyya, D., Karmakar, P. (2015). PI3K-Mediated proliferation of fibroblasts by Calendula officinalis tincture: Implication in wound healing. Phytother. Res., 29(4), 607–616. DOI: 10.1002/ptr.5293
  16. Duran, V., Matic, M., Jovanovic, M. (2005). Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int. J. Tissue. React., 27(3), 101–106.
  17. EFSA – European Food Safety Authority. Available: http://www.efsa.europa.eu/ [data of access: 11.11.2018].
  18. European Pharmacopoeia 9.0 (2017). European Directorate for the Quality of Medicines, Strasburg.
  19. EMA – European Medicines Agency. Available: https://www.ema.europa.eu/ [data of access: 06.01.2019].
  20. ESCOP – European Scientific Cooperative on Phytotherapy. Available: http://escop.com/ [data of access: 20.02.2019].
  21. Farahpour, M.R. (2014). Antioxidant activity, antinociceptive and anti-inflammatory effects of pot marigold hydroalcoholic extract on experimental animals. Int.
  22. J. PharmTech. Res., 6(5), 1640–1646.
  23. Farmakopea Polska XI (2017). Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, Warszawa.
  24. Faustino, M.V., Pinto, D.C.G.A., Gonçalves, M.J., Salgueiro, L., Silveira, P., Silva, A.M.S. (2018). Calendula L. species polyphenolic profile and in vitro antifungal activity. J. Funct. Foods, 45, 254–267. DOI: 10.1016/j.jff.2018.04.013
  25. Georgiev, V., Slavov, A., Vasileva, I., Pavlov, A. (2018). Plant cell culture as emerging technology for production of active cosmetic ingredients. Eng. Life Sci., 18(11), 779–798. DOI: 10.1002/elsc.201800066
  26. German Commission E Monographs, Phytotherapy (1986). Calendula flower (Calendulae flos) [summary of the monograph]. Available: https://buecher.heilpflanzen-welt.de/BGA-Commission-E-Monographs/0043.htm [data of access: 26.01.2019].
  27. Gilca, M., Tiplica, G.S., Salavastru, C.M. (2018). Traditional and ethnobotanical dermatology practices in Romania and other Eastern European countries. Clin. Dermatol., 36(3), 338–352, DOI: 10.1016/j.clindermatol.2018.03.008
  28. Grzelak, A., Janiszowska, W. (2002). Initiation and growth characteristics of suspension cultures of Calendula officinalis cells. Plant Cell. Tissue Organ Cult., 71, 29–40. DOI: 10.1023/A:1016553909002
  29. Hernández-Saavedra, D., Pérez-Ramírez, I.F., Ramos-Gómez, M., Mendoza-Díaz, S., Loarca-Piña, G., Reynoso-Camacho, R. (2016). Phytochemical characterization and effect of Calendula officinalis, Hypericum perforatum, and Salvia officinalis infusions on obesity-associated cardiovascular risk. Med. Chem. Res., 25(1), 163–172. DOI: 10.1007/s00044-015-1454-1
  30. Jadoon, S., Karim, S., Hassham, M., Bin, H., Akram, M.R., Khan, A.K., Malik, A., Chen, C., Murtaza, G. (2015). Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity. Oxidative Med. Cell. Longev., 2015, 1–17. DOI: 10.1155/2015/709628
  31. John, R., Andrabi, K.I., Jan, N. (2017). Calendula officinalis – an important medicinal plant with potential biological properties. Proc. Indian Natl. Sci. Acad., 83(4), 769–787. DOI: 10.16943/ptinsa/2017/49126
  32. Kaur, J., Sidhu, S., Chopra, K., Khan, M.U. (2016). Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats. Pharm. Biol., 54(12), 2951–2959. DOI: 10.1080/13880209.2016.1195848
  33. Khalid, K.A., Silva, J.A.T. (2012). Biology of Calendula officinalis Linn.: Focus on pharmacology, biological activities and agronomic practices. Med. Aromat. Plant Sci. Biotechnol. 6, 12–27.
  34. Kurkin, V.A., Sharova, O.V. (2007). Flavonoids from Calendula officinalis flowers. Chem. Nat. Compd., 43(2), 216–217. DOI: 10.1007/s10600-007-0084-3
  35. Leach, J.M. (2008). Calendula officinalis and wound healing: a systematic review. Wounds, 20(8), 236–243.
  36. Legha, M.R., Prasad, K.V., Singh, S.K., Kaur, C., Arora, A., Kumar, S. (2012). Induction of carotenoid pigments in callus cultures of Calendula officinalis L. in response to nitrogen and sucrose levels. Vitr. Cell. Dev. Biol. – Plant, 48(1), 99–106. DOI: 10.1007/s11627-011-9402-3
  37. Lima, M.R., Lopes, A.P., Martins, C., Brito, G.A.C., Carneiro, V.C., Goes, P. (2017). The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis. Front. Physiol., 8, 1–9. DOI: 10.3389/fphys.2017.00440
  38. Lohani, A., Mishra, A.K., Verma, A. (2018). Cosmeceutical potential of geranium and calendula essential oil: Determination of antioxidant activity and in vitro sun protection factor. J. Cosmet. Dermatol., 1–8. DOI: 10.1111/jocd.12789
  39. Lovecka, P., Lipov, J., Thumova, K., Macurkova, A. (2018). Characterization of biologically active substances from Calendula officinalis. Curr. Pharm. Biotechnol., 19, 1167–1174. DOI: 10.2174/1389201019666180226151910
  40. Miguel, M., Barros, L., Pereira, C., Calhelha, R.C., Garcia, P.A., Castro, M.Á., Santos-Buelga, C., Ferreira, I.C.F.R. (2016). Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves). Food Funct., 7(5), 2223–2232. DOI: 10.1039/c6fo00398b
  41. Muley, B.P., Khadabadi, S.S., Banarase, N.B. (2009). Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): A review. Trop. J. Pharm. Res., 8(5), 455–465. DOI: 10.4314/tjpr.v8i5.48090
  42. Neukirch, H., D’Ambrosio, M., Dalla Via, J., Guerriero, A. (2004). Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem. Anal., 15(1), 30–35. DOI: 10.1002/pca.739
  43. Nicolaus, C., Junghanns, S., Hartmann, A., Murillo, R., Ganzera, M., Merfort, I. (2017). In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. J. Ethnopharmacol., 196, 94–103. DOI: 10.1016/j.jep.2016.12.006.
  44. Nizyński, B., Alsoufi, A.S.M., Pączkowski, C., Długosz, M., Szakiel, A. (2015). The content of free and esterified triterpenoids of the native marigold (Calendula officinalis) plant and its modifications in in vitro cultures. Phytochem. Lett., 11, 410–417. DOI: 10.1016/j.phytol.2014.12.017
  45. Okoh, O.O., Sadimenko, A.A., Afolayan, A. (2007). The effects of age on the yield and composition of the essential oils of Calendula officinalis. J. Appl. Sci., 7(23), 3806–3810. DOI: 10.3923/jas.2007.3806.3810
  46. Okuma, C.H., Andrade, T.A.M., Caetano, G.F., Finci, L.I., Maciel, N.R., Topan, J.F., Cefali, L.C., Polizello, A.C.M., Carlo, T., Rogerio, A.P., Spadaro, A.C.C., Isaac, V.L.B., Frade, M.A.C., Rocha-Filho, P.A. (2015). Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing. Eur. J. Pharm. Sci., 71, 62–72. DOI: 10.1016/j.ejps.2015.01.016
  47. Parente, L.M.L., Souza Lino Jr, R. de, Tresvenzol, L.M.F., Vinaud, M.C., Paula, J.R. de, Paulo, N.M. (2012). Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid.-Based Complement. Altern. Med., 2012, 1–7. DOI: 10.1155/2012/375671
  48. Paul, S., Rahman, A., Mahmud, M., Uzzal, A., Das, Z. (2018). Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: a comparative approach. J. Adv. Vet. Anim. Res., 4(4), 333. DOI: 10.5455/javar.2017.d229
  49. Pedram Rad, Z., Mokhtari, J., Abbasi, M. (2019). Preparation and characterization of Calendula officinalis-loaded PCL/gum arabic nanocomposite scaffolds for wound healing applications. Iran. Polym. J., 28(1), 51–63. DOI: 10.1007/s13726-018-0674-x
  50. Pommier, P., Gomez, F., Sunyach, M.P., D’Hombres, A., Carrie, C., Montbarbon, X. (2004). Phase III randomised trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J. Clin. Oncol., 22(8), 1447–1453. DOI: 10.1200/JCO.2004.07.063
  51. Preethi, K.C., Kuttan, R. (2009). Wound healing activity of flower extract of Calendula officinalis. J. Basic Clin. Physiol. Pharmacol., 20(1), 73–79. DOI: 10.1515/jbcpp.2009.20.1.73
  52. Reider, N., Komericki, P., Hausen, B.M., Fritsch, P., Aberer, W. (2001). The seamy side of natural medicines: Contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis, 45(5), 269–272. DOI: 10.1034/j.1600-0536.2001.450503.x
  53. Ruszkowski, D., Szakiel, A., Janiszowska, W. (2005). Metabolism of [3-3H]oleanolic acid in Calendula officinalis L. root. Acta Physiol. Plant., 25(4), 311–317. DOI: 10.1007/s11738-003-0011-6
  54. Saffari, E., Mohammad-Alizadeh-Charandabi, S., Adibpour, M., Mirghafourvand, M., Javadzadeh, Y. (2017). Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial. Women Heal., 57(10), 1145–1160. DOI: 10.1080/03630242.2016
  55. Salehi, B., Anil Kumar, N.V., Şener, B., Sharifi-Rad, M., Kılıç, M., Mahady, G.B., Mehtap, K., Vlaicavljevic, S., Iriti, M., Kobarfard, F., Setzer, W.N., Ayatollahi, S.A., Ata, A., Sharifi-Rad, J. (2018). Medicinal plants used in the treatment of human immunodeficiency virus. Int. J. Mol. Sci., 19(5), 1459. DOI: 10.3390/ijms19051459
  56. Samochowiec, E., Urbanska, L., Manka, W., Stolarska, E. (1979). Assessment of the action of Calendula officinalis and Echinacea angustifolia extracts on Trichomonas vaginalis in vitro. Wiad. Parazytol., 25(1), 77–81.
  57. Shafeie, N., Naini, A.T., Jahromi, H.K. (2015). Comparison of different concentrations of Calendula officinalis gel on cutaneous wound healing. Biomed. Pharmacol. J., 8(2), 979–992. DOI: 10.13005/bpj/850
  58. Shankar, S.M., Bardvalli, S.G., Jyotirmayee, R., Chethana, Bhushan, K., Kumar, S. (2017). Efficacy of Calendula officinalis extract (marigold flower) as an antimicrobial agent against oral microbes: An in vitro study in comparison with chlorhexidine digluconate. J. Clin. Diagnostic Res., 11(10), ZC05-ZC10. DOI: 10.7860/JCDR/2017/29844.10702
  59. Shivasharan, B.D., Nagakannan, P., Thippeswamy, B.S., Veerapur, V.P., Bansal, P., Unnikrishnan, M.K. (2013). Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington’s disease in rats. Drug Chem. Toxicol., 36(4), 466–473. DOI: 10.3109/01480545.2013.776583
  60. Singh, M.K., Sahu, P., Nagori, K., Dewangan, D., Alexander, T.K.A., Badwaik, H., Tripathi, D.K. (2011). Organoleptic properties in-vitro and in-vivo pharmacological activities of Calendula officinalis Linn.: An over review. J. Chem. Pharm. Res., 3(4), 655–663.
  61. Toropova, A.A., Badmaev, N.S., Razuvaeva, Y.G., Nikolaev, S.M., Sambueva, Z.G., Erentueva, A. (2017). Influence of Calendula officinalis extract on the antioxidant and energy status of liver in rats with experimental hepatitis. Eksp. Klin. Farmakol., 80(7), 11–14.
  62. Tundis, R., Loizzo, M.R., Bonesi, M., Menichini, F. (2015). Potential role of natural compounds against skin aging. Curr. Med. Chem., 22(12), 1515–1538. DOI: 10.2174/0929867322666150227151809
  63. FDA – U.S. Food & Drug Administration. Available: https://www.fda.gov/ [data of access: 22.01.2019].
  64. Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Suzuki, T., Kimura, Y. (2006). Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of Marigold (Calendula officinalis) flowers. J. Nat. Prod., 69(12), 1692–1696. DOI: 10.1021/np068016b
  65. WHO (2002). Monographs on selected medical plants,
  66. vol. 2. Geneva.
  67. Wiktorowska, E., Długosz, M., Janiszowska, W. (2010). Significant enhancement of oleanolic and accumulation by biotic elicitors in cell suspension cultures of Calendula officinalis L. Enzyme Microb. Technol., 46, 14–20. DOI: 10.1016/j.enzmictec.2009.09.002
  68. Xuan, S.H., Kim, G.Y., Yu, J.Y., Kim, J.W., Yang, Y.R., Jeon, Y.H., Jeong, Y.J., Kim, R.A., Park, S.N. (2016). Antioxidant and cellular protective effects against oxidative stress of Calendula officinalis flowers extracts in human skin cells. Appl. Chem. Eng., 27(6), 620–626. DOI: 10.14478/ace.2016.1093
  69. Xuan, S.H., Park, Y.M., Park, S.N. (2019). Antimelanogenic and antimigration properties of the ethyl acetate fraction of Calendula officinalis flowers on melanoma cells. Photochem. Photobiol., 95(3), 860–866. DOI: 10.1111/php.13064

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