Fireweed (Epilobium angustifolium L.) is a quite common species in our country. However, in order to obtain larger quantities of high quality E. angustifolia herb, it is necessary to introduce it into cultivation. The study covered four-year field experiment (2013–2016). The aim of the study was to investigate the fireweed reaction to the impact of various levels of mineral fertilization and spacing. It has been shown that the increased amount of fertilizer components at the level of 60 N, 70 P2O5 and 100 K2O kg · ha–1 stimulated vegetative growth and had a positive effect on yielding. The highest biological efficiency of the plantation was found at the population density resulting from 45 × 30 cm spacing. Increasing the dose of mineral fertilization and increasing the plant spacing did not result in statistically proven impact on the quality of the raw material (flavonoid content).
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